In August, JT Lindholm, Tony Perelli and I completed the Nabesna to McCarthy route along the eastern flank of Wrangell-St. Elias National Park and Preserve. The trip goes through some of the most spectacular terrain in Alaska and is highly recommended.
The whole route is approximately 150 miles in length, with the majority (approximately 100 miles) on foot. The boating segments include approximately 10 miles of Class II on Jack Creek and the Nabesna, roughly 7 miles of Class II - III on Notch Creek (if you are lucky to find enough water in Notch Creek), several miles across Upper Skolai Lake and approximately 30 miles of Class II and III on the Chitistone and Nizina rivers. An additional 8 miles of Class III-IV on the Chitistone, between the bottom of the Goat Trail and Glacier Creek, can be boated or walked depending on your gear, confidence, boating skills and water level.
A shorter version of this trip can be done by flying into Skolai Pass and hiking down (and up and down) the Goat Trail to the Chitistone. This is the most spectacular portion of the trip.
There is a great set of photos of the entire route from the air and trip photos and commentary to be found at http://www.jtlindholm.com/wrangells.htm